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KMID : 0616120060370040246
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Korean Journal of Pharmacognosy
2006 Volume.37 No. 4 p.246 ~ p.252
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Effect of Heat Processed Ginseng on Anti-Fatigue
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Shin Yong-Wook
Choi Hyuck-Jai
Kim Dong-Hyun
Park Jeong-Hill
Kim Nam-Jae
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Abstract
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The effects of ginsenosides Rg3(R), Rg3(S) and Rg5/Rk1, components isolated from processed Panax ginseng C.A. Meyer(Araliaceae), on memory dysfunction were examined in mice using a passive avoidance test. Orally administered ginsenosides Rg3(R), Rg3(S) or Rg5/Rk1 for 4 days significantly ameliorated the memory impairment induced by the single oral administration of ethanol. The memory impairment induced by the intraperitoneal injection of scopolamine was also significantly recovered by ginsenosides Rg3(S) and Rg5/Rk1. Among the three ginsenosides tested in this study, Rg5/Rk1 enhanced memory function most effectively in both ethanol- and scopolamine- induced amnesia models. Moreover, the latency of Rg5/Rk1-treated mice was 1.2 times longer than that of control (no amnesia) group in both models, implying that it may also exert beneficial effects in the nomal brain.
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KEYWORD
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Ginseng, heat processed ginseng, Sun Ginseng, antioxidative, forces swimming test, antifatigue
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